ASFV-G-∆I177L vaccine reverts to virulence and impairs reproduction
npj Vaccines | ( 2025) 10:46 10 March, 2025 The ASFV-G-ΔI177L vaccine is a modified-live African swine fever virus (ASFV) strain developed as a vaccination measure against African swine fever (ASF) in pigs. This vaccine strain was created by partially deleting the I177L gene and replacing it with the mCherry reporter gene.The ASFV-G-ΔI177L strain has been incorporated into a commercially available vaccine, used to immunize pigs, particularly via intramuscular or oronasal routes. It has shown promise in protecting commercial pigs against ASFV infection. However, concerns regarding its genetic stability emerged following studies indicating that ASFV-G-ΔI177L could revert to virulence during in vivo passaging. Reversion was associated with ASF-specific clinical signs and increased viremia in infected pigs, raising concerns about its safety and effectiveness as a vaccine. Read More
CDC report strengthens evidence of HPV vaccine's role in preventing cervical cancer
1 March, 2025 A new report published in MMWR found that between 2008 and 2022, cervical precancer incidence decreased by 79%, and higher-grade precancer incidence decreased by 80% among screened women aged 20–24 years - the age group most likely to have been vaccinated.Human papillomavirus (HPV) causes approximately 10,800 cervical cancers annually in the United States, making cervical cancer the most common HPV-attributable cancer among women. Between 2008 and 2022, a total of 39,977 cases of cervical precancer were reported in the U.S. Read More
'Post-vaccination syndrome' after Covid-19 vaccination
medRxiv preprint | February 18, 2025 22 February, 2025 COVID-19 vaccines provided significant protection and prevented millions of deaths. However, in a small number of individuals, the vaccines may have led to a range of side effects, including fatigue, myalgia, brain fog, tinnitus, and dizziness, collectively referred to as 'post-vaccination syndrome,' according to a new small-scale study conducted by scientists at Yale University. Read MoreMeasles in Texas, USA
21 February, 2025 Texas health authorities recently reported an unusual measles outbreak with 90 confirmed cases (as of February 21), the majority occurring in children and adolescents. Most cases have been reported in Gaines County. Sixteen patients have been hospitalized, and most affected individuals are under the age of 18. This is the most severe measles outbreak in Texas in approximately 30 years. Four of the infected individuals were vaccinated, while the remainder were not.A study published in 2021 in Scientific Reports analyzed the rise in measles cases in the United States in the post-elimination era (the U.S. declared measles eliminated in 2000), covering the period from 2001 to 2019. Read More
