Description: A polyether divalent carboxylic ionophore. Lasalocid is an anticoccidial feed additive. It is indicated for use for the control of coccidiosis in broilers, chickens reared for laying and turkeys.
Origin: Streptomyces lasaliensis;
Dosage: 90-125 ppm
Mode of Action: The mechanism of action of lasalocid and other ionophores has been extensively investigated and reported. Like other carboxylic polyether ionophores, lasalocid disturbs ionic homeostasis, leading to osmotic lysis of coccidia.
Pharmacokinetics: Following oral administration to poultry species, lasalocid sodium is rapidly absorbed and detected in the peripheral circulation. Peak concentrations in blood are observed within two hours, with a half-life of three hours. Distribution is wide spread and rapid with lasalocid detected in all edible tissues. Metabolism in each tissue is significant, with 5–7 unidentified polar metabolites produced. Excretion of the parent moiety and metabolites is rapid and primarily via the faeces.
Toxicity: Mice LD50 146 mg/kg BW; Rat LD50 122 mg/kg BW; Chickens 71.5 mg/kg BW; Horses 21.5 mg/kg BW; Cattle 50 mg/kg BW;
Incompatibilities and interactions: Clinically important interactions between ionophore anticoccidials and the antibiotic tiamulin (and other antibiotics) are well known phenomena in chickens, turkeys and other species. Avoid concurrent administration of lasalocid with tiamulin. Avoid concurrent administration of lasalocid with chloramphenicol.
Comments: Causes excess water excretion and wet litter.
